Jaiju James Chakola
Sri Ramachandra Institute of Higher Education and Research Centre, India
Title: Prevalence and outcome of Acute Kidney Injury in dengue patients in a Tertiary care hospital, India
Biography
Biography: Jaiju James Chakola
Abstract
Dengue is a growing public health problem and AKI is one of the major complications of dengue virus infection. A total 922 dengue patients (2017–2018) were retrospectively evaluated and were stratified into AKI and non-AKI groups. Two groups were compared using appropriate statistical methods. There were 103 patients (11.2%) who had AKI, with AKIN-I, II and III in 68.8%, 23.6% and 7.6% patients, respectively. Significant differences (P<0.05) in demographics and clinic-laboratory characteristics were observed between patients with and without AKI. Presence of DHF [OR (95% CI): 8.0 (3.64–17.59), P<0.001], rhabdomyolysis [OR (95% CI): 7.9 (3.04–20.49)], MODS [OR (95% CI): 34.6 (14.14–84.73), P<0.001], diabetes mellitus [OR (95% CI): 4.7 (1.12–19.86), P = 0.034], late hospitalization [OR (95% CI): 2.1 (1.12–19.86), P = 0.033] and use of nephrotoxic drugs [OR (95% CI): 2.9 (1.12–19.86), P = 0.006] were associated with AKI. Longer hospital stay (>7 days) was also observed among AKI patients (OR = 1.3, P = 0.044). Additionally, 24.5% AKI patients had renal insufficiencies at discharge that were significantly associated with severe dengue. Overall mortality was 1.8% and all fatal cases had AKI. The incidence of AKI is high at 11.2% among dengue patients, and those with AKI portended significant morbidity, mortality, longer hospital stay and poor renal outcomes.